张鲁嘉课题组

Academic Awards

1. Research and application of enzyme preparations for the extraction of bioactive substances from plant sources China Chamber of Commerce, China Chamber of Commerce Science and Technology Award, National Commercial Science and Technology Progress Award, First Prize, 2016 2. Chiral Non Natural Amino Acid Biocatalytic Preparation Technology and Its Applications Shanghai Municipal People's Government, Shanghai Science and Technology Progress Award, First Prize, 2013 3. Key Technologies for the Creation and Industrialization of Industrial Enzyme Preparations Shanghai Municipal People's Government, Shanghai Science and Technology Progress Award, First Prize, 2010 4. Key technologies and applications of rational transformation of biological enzymes and efficient fermentation Hubei Provincial People's Government, Science and Technology Progress Award, Second Prize, 2017 5. Key Technologies and Applications of Biological Manufacturing of Marine Food, State Oceanic Administration (China Ocean Engineering Consulting Association), National Ocean Engineering Science and Technology Award, Second Prize, 2017

Teaching Awards

In 2021, the 2nd National College Student Chemistry Experiment Innovation Design Competition "Weirui Cup" East China Division won the second prize. In 2022, the 16th Shanghai College Student Chemistry Experiment Competition "Leyan Cup" won the special prize

Apply for and authorize patents

Application of a sulfur redox protein in promoting enzymatic hydrolysis of keratin 2024/05/24, China, ZL202410654353.7 A P450BM3 enzyme mutant that can efficiently utilize non natural cofactors and its expression application 2023/07/21, China, CN2023109017609 A molecular modification design method for improving substrate selectivity of proline endopeptidase 2023/07/19, China, 2023108883454 A high esterification ability lipase mutant and its expression application May 18, 2023, China, CN116426500 An artificially modified enzyme with high enzymatic activity for gastric protease and its molecular modification method and expression application. November 22, China, CN202211425013.4 An artificially modified enzyme with high thermal stability for gastric protease and its expression application November 2022, China, CN202211425015.3 A denaturation method for trastuzumab single chain antibodies and single chain antibodies homologous to their sequences May 2022, China, CN202210550377.9 A method for refolding a umami receptor recombinant protein inclusion body 2022/04, China, CN202210392025.5 An artificially modified enzyme based on glucose oxidase and its expression application 2022/03, China, CN202111356602.7 A molecular modification design method for improving the catalytic efficiency of prolyl endopeptidase 2022/04, China, ZL202010300809.1 A method for enzyme immobilization and its application 2020/11, China, ZL 201710444356.8 A genetically engineered strain and construction method for expressing a D domain fusion protein of microtubule β subunit and protein A, 2020/11, China, ZL202010207523.9 An antibody mimic based on yeast dipeptidyl peptidase III and its application, 2020/10, China, ZL202010192357. X A protein fusion design method based on α - helix fusion of two proteins while maintaining the activity of their respective subunits, 2020/10, China, ZL 202010192367.3 A fermented product of turbot skin with antioxidant activity. 2016/06, China, ZL201610390378. An aspartic protease and its encoding gene and application 2016/01, China, ZL201610052686.8 A α - amylase and its coding gene and application 2016/01 China, ZL 201610052870.2 A biological preparation method for niacin, related strains, and their nitrile hydrolase induction method 2010/12, China, ZL 200910050127.3

Authorize national software copyright

1. Functional protein performance parameter analysis system V1.0, national software copyright registration number: 2023SR1557319, 2022 2. Enzyme protein element data analysis platform V1.0, national software copyright registration number: 2023SR1549258, 2022 3. Light industry enzyme big data intelligent analysis platform V1.0, national software copyright registration number: 2023SR02689722022 4. Enzyme molecule substrate selective intelligent design system V1.0, national software copyright registration number: 2022SR1244439, 2022 5. High stability functional protein bidirectional design software V2.0, national software copyright registration number: 2022SR1337677, 2022

Research project

1. The Ministry of Science and Technology of the People's Republic of China, a national key research and development program, 2020YFA0908402, molecular mechanism research on the active function of protein elements, 2020-11 to 2025-10, presided over 2. The Ministry of Science and Technology of the People's Republic of China, a sub project of the national key research and development program, 2021YFC2100400, molecular design and intelligent manufacturing of enzyme preparations for light industry, 2021-07-2024-6, presided over 3. The Ministry of Science and Technology of the People's Republic of China, a sub project of the national key research and development program, 2021YFC2102400, molecular design and efficient production of key oxidoreductases for light industry, 2021-07-2024-6, presided over Subproject, 2019YFA0905200, Cell Design, Construction and Application of Artificial Protein Synthesis, January 2020-2024-12, presided over 5. State Key Laboratory of "Material Chemistry Engineering", open project (bidding project), KL19-12， Accurate Design and Efficient Expression of High Performance Protein Adhesive Materials, 2020-01 to 2021-12, Hosted by 6. National Natural Science Foundation of China, Joint Fund Key Project, U1805235， Determination of active ingredients and exploration of value-added utilization pathways in Guanxi honey pomelo, a characteristic citrus fruit in Fujian Province, from January 2019 to December 2022. Hosted by 7. National Postdoctoral Fund General Project (First Class), 59 batches, 2016M590661, directed processing of specific structural functional lipids based on rational design of high specificity lipase, from July 2016 to December 2017. Hosted by 8. National Natural Science Foundation of China, National Natural Science Foundation of China Guangdong Provincial Government Joint Fund (Phase II), U1501501， "Tianhe No.2" Supercomputer Application Project, January 2016 to December 2017, presided over 9. National Natural Science Foundation of China, general project, 31571786, research on new strategy of controllable tandem enzymolysis of protein food based on the analysis of high activity angiotensin converting enzyme inhibiting oligopeptide metabolism and structure activity mechanism, January 2016 to December 2019, presided over 10. Open project of State Key Laboratory of Bioreactor Engineering, "State Key Laboratory of Bioreactor Engineering", research on degradation mechanism of C22 site of side chain of mycosterol C17, June 2015 to May 2018, presided over 11. East China University of Technology, basic scientific research business of central universities Special funds for, W1214057， Design and development of lipase virtual substrate screening system based on high-performance computing, October 2012 to September 2014, presided over 12. The Ministry of Science and Technology of the People's Republic of China, the National "863" Program, 2012AA020403, research and application of key technologies for large-scale transformation of enzyme molecules, January 2012 to December 2015, presided over 13. The State Key Laboratory of Materials Chemistry Engineering, an open project, KL10-09， Research on the Reaction Mechanism of Biomass Derivatives Catalyzed by Lipase, January 2010 to December 2012, Hosted 14. Shanghai Huayi (Group) Co., Ltd., Technical Research Project of East China University of Science and Technology Research Center, Biological Production of S-Adenosylmethionine, January 2007 to December 2010, Hosted 15. Tianluo Diagnostic Technology Jiangsu Co., Ltd., Enterprise Commissioned Project, Research and Application of Enzyme Substrate Spectrum Expansion for Nucleic Acid Detection and Diagnosis, January 2020 to December 2023, Hosted 16. Ningxia Xiasheng Industrial Co., Ltd., Enterprise Commissioned Project, Activity Modification of Protease and Other Industrial Enzyme Preparations, December 2018 to November 2024, Hosted 17. National Natural Science Foundation of China, Key Project, 31630078 The mechanism of action of insulin degrading enzymes in the invasion of Cryptosporidium, 2017/01-2021/12, involved in 18 National Natural Science Foundation of China, Youth Project, 31301413, Research on the Structure Activity Relationship of Computer Assisted Screening of Blood Pressure Reducing Peptides from Stellaria, January 2014 to December 2016, Participated in 19. Ministry of Science and Technology of China, National "973" Program Project, 2012CB721000, Structure Activity Relationship and Evolution of Several Important Enzyme Proteins Related to Microbial Drug Synthesis, January 2012 to October 2016, Participated in 20. Ministry of Science and Technology of China, "Major New Drug Creation" Science and Technology Major Special Project, 2009ZX09306-001, Biotechnology Drug Pilot Scale up and Separation Purification Technology Platform, January 2012 to December 2015, Participated in 21. East China University of Science and Technology, Central University Interdisciplinary and Major Project Cultivation Fund, (Approval Number), New Biocatalyst Creation Method and Industrial Application Technology, January 2011 to December 2014, Participated in 22 Ministry of Science and Technology, National "973" Program Project, 2009CB724700, Scientific Basis of New Generation Biocatalysis and Biotransformation, from January 2009 to August 2013, participated in

Academic Reports

1. Research on Rational Design Strategies Based on the Dynamic Behavioral Characteristics of Enzyme Molecules, Invited Report, 10th International Conference on Molecular Simulation and Artificial Intelligence Applications; 2. Regulation of primary and secondary reactions of nitrate, invited report, 2nd International Forum on Synthetic Biology, Nanjing, China, September 24, 2019 to September 26, 2019. 3. Analysis and rational design of protease cleavage site selectivity mechanism, conference report, 12th China Enzyme Engineering Academic Symposium, Changchun, China, August 8-11, 2019. 4. Recognition and rational design of spatial selectivity mechanism of nitrile hydrolase, conference report, 8th International Molecular Simulation and Information Technology Application Academic Conference, Dalian, China, September 24-26, 2016. Development of Growth Software, Conference Report, 12th National Symposium on Enzymology, Conference Report, Weihai, China, September 18-September 20, 2015 6 New technology for predicting substrate profiles of enzymes, conference report, 2015 China Enzyme Engineering and Sugar Bioengineering Academic Symposium, "Novozymes Youth Excellent Report" Award, Zhenjiang, China, August 21-August 23, 2015 7. Research on rational design strategies of enzyme molecules and application software development, invited report, 7th International Molecular Simulation and Information Technology Application Academic Conference, Suzhou, China, October 26-10.28, 2014 8. Building bridges between structure and function, invited report, 6th International Molecular Simulation and Information Technology Application Academic Conference, Nanjing, China, May 13-5.1, 2012